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Product Description

Other VB 12 derivatives include adeninylalkylcobalamin, 25mg viagra effective (AdeEtCbl), adeninylpropylcobalamin (AdePrCbl) and adeninylpentylcobalamin (AdePeCbl)). Alternative derivatives of VB 12 include the mono, di- and tricarboxylic acid derivatives or the propionamide derivatives of VB 12. Alternatively, suitable analogs of VB 12 viaga those in which the cobalt ion is replaced by either a zinc or nickel ion. Other derivatives and analogs 25kg vitamin B12 are discussed in Schneider and Stroinski, Comprehensive B 12, Walter De Gruyter, Berlin, NY, 1987, the disclosure of which is incorporated herein by reference. In a related embodiment, the active agent of the present invention comprises aquocobalamin, adenosylcobalamin, methylcobalamin, hydroxycobalamin, cyanocobalamin, carbanalide, or 5 methoxybenzylcyanocobalamin [(5-MeO)CN-CbI]. Without limiting the scope of the invention, VB 12 analogs or derivatives of the present invention are involved in the sequestration andor neutralization of nitric oxide and other reactive nitrogen species. Thus, nitric oxide and nitric superoxide rapidly combine to form a toxic reaction product, peroxynitrite anion (ONOO). The ratio of superoxide to NO is important in determining the reactivity of peroxynitrite: excess NO or excess superoxide reduces the oxidation elicited by peroxynitrite. The oxidant borettslaget iladalen viagra of peroxynitrite is mediated by an intermediate with the biological activity of the hydroxyl radical.

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