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Volunteers receive either a topical phaŌnaceutical composition, for example, one of those described above in Examples 3 or 7 or topical placebo for an appropriate period, for example, a single 0. 8ml application on one psoriatic lesion (total skin area of 20 cm2) with a 7 day follow-up or, alternatively, multiple 0. 8ml applications on the same target lesion 9 times (every second day) over a 21 day period. Biological parameters associated with the indicated disease state or condition, for example, psoriasis, will be measured at the beginning (baseline measurements before any treatment), end (after the final treatment), and at regular intervals during the study period. Such measurements include the levels of TNF alpha in body fluids, tissues or organs compared to pre-treatment levels. Other measurements include, but are not limited to, indices of the disease state or condition being treated, body weight, blood pressure, serum titers of pharmacologic indicators of disease or toxicity as well as ADME (absorption, distribution, metabolism and excretion) measurements. Information recorded for each patient includes age (years), gender, height (cm), family history of disease state or condition (yesno), motivation rating (somemoderategreat) and number and type of previous high altitude pulmonary edema viagra regimens for the indicated disease or condition. Volunteers taking part in this study are adults aged 18 to 65 years and exhibit a particular actenacol gocce dosaggio viagra disorder, for example, psoriatic skin lesions. Additionally, roughly an equal number of males and females participate in the study.

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