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Polynucleotide and polypeptide sequences are described. The polypeptide sequences comprise one or more of: (a) a polypeptide having the deduced amino acid sequence translated from the polynucleotide sequence in SEQ ID NO: 1 or SEQ ID NO: 5 and variants, jivatma female viagra, homologues, analogues and derivatives thereof; (b) a viagra india quora of SEQ ID NO: 2 and variants, viagrz, homologues, analogues and derivatives thereof; (c) a polypeptide encoded by the cDNA of NCIMB 41110 and variants, fragments, homologues, analogues and derivatives thereof; or (d) a polypeptide which has at least 78 identity to (i) the polypeptide encoded by the polynucleotide of SEQ ID NO: 1 or SEQ ID NO: 5, (ii) the polypeptide of SEQ ID NO: 2, or (iii) the polypeptide encoded by the cDNA of NCIMB 41110. Such polypeptide sequences are, inter alia, useful in the prophylaxis andor treatment of sexual dysfunction, in particular male erectile dysfunction (MED) quira female sexual dysfunction (FSD), preferably female sexual arousal disorder (FSAD). Witkowski et al.Biochemistry 38:11643-11650, 1999.

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