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The present invention provides a topical delivery system which assists in the penetration of a desired active agent, such as peptides, polypeptides and proteins, water soluble vitamins, NSAIDs, genetic molecules and chemical compounds into the skin, which does not necessitate the use of chemical enhancers, nor electrical or ultrasonic energy to facilitate penetration into and though the skin. Furthermore, the delivery system is easy to apply to small or large areas of the skin. The present invention further enables the use of hydrophilic molecules which are incorporated within the submicron sized water droplets contained within the microemulsion, thereby enhancing transdermal delivery of desired active agents. The topical delivery system of the present invention is in the form of a microemulsion. The subject microemulsions for transdermal delivery of peptides, polypeptides and proteins or other molecules such as water soluble vitamins, NSAIDs, genetic molecules and chemical compounds are able to be formed with little or no shear force applied to the molecules during the preparation of the microemulsion, which aids in the preservation of the structure and bioactivity of these molecules.

Profitability declines toward more normal levels as investment matures and new output is brought onto the market. Commodity prices decline. The farm economy goes into recession.]